Ipamorelin 2acetate(170851-70-4(free base))

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Ipamorelin 2acetate 是一种生长激素释放肽，可诱导大鼠纵向骨生长。在体外，伊帕瑞林从原代大鼠垂体细胞中释放 GH，其效力和功效与 GHRP-6 (ECs) 相似 = 1.3+/-0.4nmol/ l 和 Emax = 85+/-5% 对比 2.2+/-0.3nmol/l 和 100%）。

Ipamorelin 2acetate is a growth-hormone-releasing peptide, induces longitudinal bone growth in rats.In vitro, ipamorelin released GH from primary rat pituitary cells with a potency and efficacy similar to GHRP-6 (ECs) = 1.3+/-0.4nmol/l and Emax = 85+/-5% vs 2.2+/-0.3nmol/l and 100%).?A pharmacological profiling using GHRP and growth hormone-releasing hormone (GHRH) antagonists clearly demonstrated that ipamorelin, like GHRP-6, stimulates GH release via a GHRP-like receptor[1]In pentobarbital anaesthetised rats, ipamorelin released GH with a potency and efficacy comparable to GHRP-6 (ED50 = 80+/-42nmol/kg and Emax = 1545+/-250ng GH/ml vs 115+/-36nmol/kg and 1167+/-120ng GH/ml).?In conscious swine, ipamorelin released GH with an ED50 = 2.3+/-0.03 nmol/kg and an Emax = 65+/-0.2 ng GH/ml plasma.?Again, this was very similar to GHRP-6 (ED50 = 3.9+/-1.4 nmol/kg and Emax = 74+/-7ng GH/ml plasma).?

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NNC-26-0161

Others

Other Targets

Others

Digestive system

Ileus

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711.85

C38H49N9O5

>98% (HPLC)

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CC(C)(C)C(O)=O.CC(C)(C)C(O)=O.CC(C)(N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O

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(-20℃)

With Ice Pack

≥ 2 years